TLR2 2258 G>A single nucleotide polymorphism and the risk of congenital infection with human cytomegalovirus.

ABSTRACT:

Background

Human cytomegalovirus (HCMV) is responsible for the most common intrauterine infections, which may be acquired congenitally from infected pregnant woman to fetus. The research was aimed to estimate the role of three single nucleotide polymorphisms (SNPs) located in TLR2 gene, and the common contribution of TLR2, and previously studied TLR4 and TLR9 SNPs, to the occurrence of congenital HCMV infection in fetuses and newborns.

Methods

The study was performed in 20 Polish fetuses and newborns, congenitally infected with HCMV, and in 31 uninfected controls, as well as with participation of pregnant women, the mothers of 16 infected and 14 uninfected offsprings. Genotypes in TLR2 SNPs were determined, using self-designed nested PCR-RFLP assays, and confirmed by sequenc

SUBMITTER: Wujcicka W 

PROVIDER: S-EPMC5260049 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature