Integrative analysis of methylation and transcriptional profiles to predict aging and construct aging specific cross-tissue networks.

ABSTRACT:

Background

Aging is a complex process relating multi-scale omics data. Finding key age markers in normal tissues could help to provide reliable aging predictions in human. However, predicting age based on multi-omics data with both accuracy and informative biological function has not been performed systematically, thus relative cross-tissue analysis has not been investigated entirely, either.

Results

Here we have developed an improved prediction pipeline, the Integrating and Stepwise Age-Prediction (ISAP) method, to regress age and find key aging markers effectively. Furthermore, we have performed a serious of network analyses, such as the PPI network, cross-tissue networks and pathway interaction networks.

Conclusion

Our results find important coordinated aging patte

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5260078 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature