Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding.

ABSTRACT: Low birth weight (LBW) individuals exhibit a disproportionately increased, incomplete fatty acid oxidation and a decreased glucose oxidation, compared with normal birth weight (NBW) individuals, and furthermore have an increased risk of developing insulin resistance and type 2 diabetes. We hypothesized that changes in amino acid metabolism may occur parallel to alterations in fatty acid and glucose oxidation, and could contribute to insulin resistance. Therefore, we measured fasting plasma levels of 15 individual or pools of amino acids in 18 LBW and 25 NBW men after an isocaloric control diet and after a 5-day high-fat, high-calorie diet. We demonstrated that LBW and NBW men increased plasma alanine levels and decreased valine and leucine/isoleucine levels in response to overfeeding. Also

SUBMITTER: Ribel-Madsen A 

PROVIDER: S-EPMC5260087 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature