Initial therapeutic strategy of invasive candidiasis for intensive care unit patients: a retrospective analysis from the China-SCAN study.

ABSTRACT:

Background

To investigate the impact of initial antifungal therapeutic strategies on the prognosis of invasive Candida infections (ICIs) in intensive care units (ICUs) in China.

Methods

A total of 306 patients with proven ICIs in the China-SCAN study were analyzed retrospectively. Empiric, pre-emptive, and targeted therapy were adopted based on starting criteria including clinical, microbiological, and other conventional prediction rules. The primary outcome was hospital mortality and the secondary endpoints were duration days in ICU and duration days in hospital. The global responses (clinical and microbiological) at the end of the empirical therapy were also assessed.

Results

A total of 268/306 (87.6%) ICI patients received antifungal therapy, including 142/268 (53.

SUBMITTER: Cui N 

PROVIDER: S-EPMC5260133 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature