Rapidly cycling Lgr5⁺ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk.

ABSTRACT: The majority of colon tumors are driven by aberrant Wnt signaling in intestinal stem cells, which mediates an efficient route toward initiating intestinal cancer. Natural lipophilic polyphenols and long-chain polyunsaturated fatty acids (PUFAs) generally suppress Wnt- and NF-κB- (nuclear factor-κ light-chain enhancer of activated B-cell) related pathways. However, the effects of these extrinsic agents on colonic leucine-rich repeat-containing G-protein-coupled receptor 5-positive (Lgr5⁺) stem cells, the cells of origin of colon cancer, have not been documented to date. Therefore, we examined the effect of n-3 PUFA and polyphenol (curcumin) combination on Lgr5⁺ stem cells during tumor initiation and progression in the colon compared with an n-6 PUFA-enriched control di

SUBMITTER: Kim E 

PROVIDER: S-EPMC5260883 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature