Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light.

ABSTRACT: Age-related macular degeneration (AMD), the leading cause of visual loss after the age of 60 years, is a degenerative retinal disease involving a variety of environmental and hereditary factors. Although it has been implicated that immune system is involved in the disease progression, the exact role that microglia has is still unclear. Here we demonstrated that knockout of Ccr2 gene could alleviate photoreceptor cell death in mice retinas exposed to chronic blue light. In Ccr2^-/- mice, a damaged microglia recruitment was shown in retina and this could protect the visual function in electroretinogram and alleviate the photoreceptor apoptosis, which thus helped attenuate the blue light-induced retinopathy. We further found an increased co-location of NLRP3, Iba-1, and IL-1β in flu

SUBMITTER: Hu Z 

PROVIDER: S-EPMC5260896 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature