TRAP1 downregulation in human ovarian cancer enhances invasion and epithelial-mesenchymal transition.

ABSTRACT: Ovarian cancer (OC) is the second leading cause of gynecological cancer death worldwide. Although the list of biomarkers is still growing, molecular mechanisms involved in OC development and progression remain elusive. We recently demonstrated that lower expression of the molecular chaperone TRAP1 in OC patients correlates with higher tumor grade and stage, and platinum resistance. Herein we show that TRAP1 is often deleted in high-grade serous OC patients (N=579), and that TRAP1 expression is correlated with the copy number, suggesting this could be one of the driving mechanisms for the loss of TRAP1 expression in OC. At molecular level, downregulation of TRAP1 associates with higher expression of p70S6K, a kinase frequently active in OC with emerging roles in cell migration and tumor met

SUBMITTER: Amoroso MR 

PROVIDER: S-EPMC5260997 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature