Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases.

ABSTRACT: Although both incidence and aggressiveness of ovarian malignancy rise with age, the exact reason for this tendency, in particular the contribution of senescent cells, remains elusive. In this project we found that the patient's age determines the frequency of intraperitoneal metastases of ovarian cancer. Moreover, we documented that senescent human peritoneal mesothelial cells (HPMCs) stimulate proliferation, migration and invasion of ovarian cancer cells in vitro, and that this effect is related to both the activity of soluble agents released to the environment by these cells and direct cell-cell contact. The panel of mediators of the pro-cancerous activity of senescent HPMCs appeared to be cancer cell line-specific. The growth of tumors in a mouse peritoneal cavity was intensified when t

SUBMITTER: Mikula-Pietrasik J 

PROVIDER: S-EPMC5261005 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature