Cullin-4 regulates Wingless and JNK signaling-mediated cell death in the Drosophila eye.

ABSTRACT: In all multicellular organisms, the fundamental processes of cell proliferation and cell death are crucial for growth regulation during organogenesis. Strict regulation of cell death is important to maintain tissue homeostasis by affecting processes like regulation of cell number, and elimination of unwanted/unfit cells. The developing Drosophila eye is a versatile model to study patterning and growth, where complex signaling pathways regulate growth and cell survival. However, the molecular mechanisms underlying regulation of these processes is not fully understood. In a gain-of-function screen, we found that misexpression of cullin-4 (cul-4), an ubiquitin ligase, can rescue reduced eye mutant phenotypes. Previously, cul-4 has been shown to regulate chromatin remodeling, cell cycle and ce

SUBMITTER: Tare M 

PROVIDER: S-EPMC5261020 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature