Large-scale pharmacological profiling of 3D tumor models of cancer cells.

ABSTRACT: The discovery of chemotherapeutic agents for the treatment of cancer commonly uses cell proliferation assays in which cells grow as two-dimensional (2D) monolayers. Compounds identified using 2D monolayer assays often fail to advance during clinical development, most likely because these assays do not reproduce the cellular complexity of tumors and their microenvironment in vivo. The use of three-dimensional (3D) cellular systems have been explored as enabling more predictive in vitro tumor models for drug discovery. To date, small-scale screens have demonstrated that pharmacological responses tend to differ between 2D and 3D cancer cell growth models. However, the limited scope of screens using 3D models has not provided a clear delineation of the cellular pathways and processes that diff

SUBMITTER: Mathews Griner LA 

PROVIDER: S-EPMC5261027 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature