Paternal age and schizophrenia: a population based cohort study.

ABSTRACT:

Objective

To investigate the association of paternal age at conception with the risk of offspring developing schizophrenia.

Design

A population based cohort study.

Setting

Sweden.

Subjects

754,330 people born in Sweden between 1973 and 1980 and still alive and resident in Sweden at age 16 years.

Main outcome measures

Hospital admission with schizophrenia or non-schizophrenic, non-affective psychosis.

Results

After adjustment for birth related exposures, socioeconomic factors, family history of psychosis, and early parental death the overall hazard ratio for each 10 year increase in paternal age was 1.47 (95% confidence interval 1.23 to 1.76) for schizophrenia and 1.12 (0.98 to 1.29) for non-schizophrenic non-affective psychosis. This association b

SUBMITTER: Sipos A 

PROVIDER: S-EPMC526116 | biostudies-literature | 2004 Nov

REPOSITORIES: biostudies-literature