Neutrophil Interactions Stimulate Evasive Hyphal Branching by Aspergillus fumigatus.

ABSTRACT: Invasive aspergillosis (IA), primarily caused by Aspergillus fumigatus, is an opportunistic fungal infection predominantly affecting immunocompromised and neutropenic patients that is difficult to treat and results in high mortality. Investigations of neutrophil-hypha interaction in vitro and in animal models of IA are limited by lack of temporal and spatial control over interactions. This study presents a new approach for studying neutrophil-hypha interaction at single cell resolution over time, which revealed an evasive fungal behavior triggered by interaction with neutrophils: Interacting hyphae performed de novo tip formation to generate new hyphal branches, allowing the fungi to avoid the interaction point and continue invasive growth. Induction of this mechanism was independent of ne

SUBMITTER: Ellett F 

PROVIDER: S-EPMC5261818 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature