Endothelial notch signaling is essential to prevent hepatic vascular malformations in mice.

ABSTRACT:

Unlabelled

Liver vasculature is crucial for adequate hepatic functions. Global deletion of Notch signaling in mice results in liver vascular pathologies. However, whether Notch in endothelium is essential for hepatic vascular structure and function remains unknown. To uncover the function of endothelial Notch in the liver, we deleted Rbpj, a transcription factor mediating all canonical Notch signaling, or Notch1 from the endothelium of postnatal mice. We investigated the hepatic vascular defects in these mutants. The liver was severely affected within 2 weeks of endothelial deletion of Rbpj from birth. Two-week old mutant mice had enlarged vessels on the liver surface, abnormal vascular architecture, and dilated sinusoids. Vascular casting and fluorosphere passage experiments indic

SUBMITTER: Cuervo H 

PROVIDER: S-EPMC5261867 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature