Feedforward and feedback frequency-dependent interactions in a large-scale laminar network of the primate cortex.

ABSTRACT: Interactions between top-down and bottom-up processes in the cerebral cortex hold the key to understanding attentional processes, predictive coding, executive control, and a gamut of other brain functions. However, the underlying circuit mechanism remains poorly understood and represents a major challenge in neuroscience. We approached this problem using a large-scale computational model of the primate cortex constrained by new directed and weighted connectivity data. In our model, the interplay between feedforward and feedback signaling depends on the cortical laminar structure and involves complex dynamics across multiple (intralaminar, interlaminar, interareal, and whole cortex) scales. The model was tested by reproducing, as well as providing insights into, a wide range of neurophysiol

SUBMITTER: Mejias JF 

PROVIDER: S-EPMC5262462 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature