Frailty, Kidney Function, and Polypharmacy: The Atherosclerosis Risk in Communities (ARIC) Study.

ABSTRACT:

Background

Frail individuals are at increased risk for poor outcomes, including adverse drug events. Kidney function is often compromised in frailty and is a key consideration in medication choice and dosing; however, creatinine-based measures of kidney function may be biased in frail individuals.

Study design

Observational study.

Setting & participants

4,987 community-dwelling older men and women with complete data who participated in visit 5 of the Atherosclerosis Risk in Communities (ARIC) Study (2011-2013).

Predictors

Kidney measures included glomerular filtration rate (GFR) estimated using serum creatinine (eGFR_cr) and serum cystatin C level (eGFR_cys) and urine albumin-creatinine ratio.

Outcome

Frailty, defined using establishe

SUBMITTER: Ballew SH 

PROVIDER: S-EPMC5263025 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature