Phosphorus Additives and Albuminuria in Early Stages of CKD: A Randomized Controlled Trial.

ABSTRACT:

Background

Little is known about the effects of phosphorus additives on patients with kidney disease.

Study design

Randomized, double-blind, crossover trial.

Setting & participants

31 adults with early stages of presumed chronic kidney disease (estimated glomerular filtration rate ≥ 45mL/min/1.73m²; urine albumin-creatinine ratio sex-specific cutoff points: men ≥ 17mg/g, women ≥ 25mg/g).

Intervention

Higher versus lower phosphorus intake for 3 weeks. Higher phosphorus intake was achieved by the addition of commercially available diet beverages and breakfast bars to diet.

Outcomes

Change in 24-hour urine albumin excretion and plasma fibroblast growth factor 23 level.

Measurements

Two 24-hour urine collections and a single fasting blood d

SUBMITTER: Chang AR 

PROVIDER: S-EPMC5263092 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature