Splenectomy Does Not Improve Long-Term Outcome After Stroke.

ABSTRACT:

Background and purpose

Immune responses to brain antigens after stroke contribute to poor outcome. We hypothesized that splenectomy would lessen the development of such responses and improve outcome.

Methods

Male Lewis rats (275-350 g) underwent 2-hour middle cerebral artery occlusion immediately after splenectomy or sham splenectomy. Animals were survived to 4 weeks (672 hrs), and immune responses to myelin basic protein determined at euthanasia. Infarct volume was determined in a subset of animals euthanized at 72 hours. Behavioral outcomes were assessed to 672 hours.

Results

Splenectomy was associated with worse neurological scores early after stroke, but infarct size at 72 hours was similar in both groups. Behavioral outcomes and immune responses to myelin basic p

SUBMITTER: Zierath D 

PROVIDER: S-EPMC5263103 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature