Low abundance of colonic butyrate-producing bacteria in HIV infection is associated with microbial translocation and immune activation.

ABSTRACT:

Objective

Gut microbial translocation is a major driving force behind chronic immune activation during HIV-1 infection. HIV-1-related intestinal dysbiosis, including increases in mucosa-associated pathobionts, may influence microbial translocation and contribute to mucosal and systemic inflammation. Thus, it is critical to understand the mechanisms by which gut microbes and their metabolic products, such as butyrate, influence immune cell function during HIV-1 infection.

Design

A cross-sectional study was performed to compare the relative abundance of butyrate-producing bacterial (BPB) species in colonic biopsies and stool of untreated, chronic HIV-1-infected (n = 18) and HIV-1-uninfected (n = 14) study participants. The effect of exogenously added butyrate on gut T-cell act

SUBMITTER: Dillon SM 

PROVIDER: S-EPMC5263163 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature