Cystatin C and Cardiac Measures in Children and Adolescents With CKD.

ABSTRACT:

Background

Cardiovascular disease (CVD) is highly prevalent among children with chronic kidney disease (CKD). Cystatin C is an established marker of kidney function and an emerging biomarker for CVD events. We quantified the relationship between cystatin C level and cardiac structure and function over time among children with CKD and assessed whether cystatin C level and diastolic function retained an association after accounting for kidney function.

Study design

Prospective cohort study.

Setting & participants

678 children and adolescents with mild to moderate CKD enrolled in the CKD in Children (CKiD) Study with 1,228 echocardiographically obtained cardiac structure and function measurements.

Predictor

Serum cystatin C (mg/L) measured annually.

Outcomes

SUBMITTER: Brady TM 

PROVIDER: S-EPMC5263171 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature