ABCA1/ApoE/HDL Pathway Mediates GW3965-Induced Neurorestoration After Stroke.

ABSTRACT:

Background and purpose

ATP-binding cassette transporter A1 (ABCA1) is a major reverse cholesterol transporter and plays critical role in the formation of brain high-density lipoprotein (HDL) cholesterol. Apolipoprotein E (ApoE) is the most abundant apolipoprotein and transports cholesterol into cells in brain. ABCA1 and ApoE are upregulated by liver-X receptors. Activation of liver-X receptors has neurorestorative benefit for stroke. The current study investigates whether ABCA1/ApoE/HDL pathway mediates GW3965, a synthetic dual liver-X receptor agonist, induced neurorestoration after stroke.

Methods

Middle-aged male specific brain ABCA1-deficient (ABCA1^-B/-B) and floxed-control (ABCA1^fl/fl) mice were subjected to distal middle-cerebral artery occlusion

SUBMITTER: Cui X 

PROVIDER: S-EPMC5263181 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature