Genome wide analysis of common and specific stress responses in adult drosophila melanogaster.

ABSTRACT:

Background

During their life, multicellular organisms are challenged with oxidative stress. It is generated by several reactive oxygen species (ROS), may limit lifespan and has been related to several human diseases. ROS can generate a wide variety of defects in many cellular components and thus the response of the organism challenged with oxidative stress may share some features with other stress responses. Conversely, in spite of recent progress, a complete functional analysis of the transcriptional responses to different oxidative stresses in model organisms is still missing. In addition, the functional significance of observed transcriptional changes is still elusive.

Results

We used oligonucleotide microarrays to address the specificities of transcriptional responses of

SUBMITTER: Girardot F 

PROVIDER: S-EPMC526417 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature