Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis.

ABSTRACT:

Objectives

To assess the safety of intra-articular (IA) autologous tolerogenic dendritic cells (tolDC) in patients with inflammatory arthritis and an inflamed knee; to assess the feasibility and acceptability of the approach and to assess potential effects on local and systemic disease activities.

Methods

An unblinded, randomised, controlled, dose escalation Phase I trial. TolDC were differentiated from CD14+ monocytes and loaded with autologous synovial fluid as a source of autoantigens. Cohorts of three participants received 1×10⁶, 3×10⁶ or 10×10⁶ tolDC arthroscopically following saline irrigation of an inflamed (target) knee. Control participants received saline irrigation only. Primary outcome was flare of disease in the target knee withi

SUBMITTER: Bell GM 

PROVIDER: S-EPMC5264217 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature