Ontology highlight
ABSTRACT:
SUBMITTER: Matsunaga N
PROVIDER: S-EPMC5264248 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
EBioMedicine 20161006
Chronic kidney disease (CKD) is a global health problem, and novel therapies to treat CKD are urgently needed. Here, we show that inhibition of G<sub>0</sub>/G<sub>1</sub> switch 2 (G0s2) ameliorates renal inflammation in a mouse model of CKD. Renal expression of chemokine (C-C motif) ligand 2 (Ccl2) was increased in response to p65 activation in the kidneys of wild-type 5/6 nephrectomy (5/6Nx) mice. Moreover, 5/6Nx Clk/Clk mice, which carry homozygous mutations in the gene encoding circadian lo ...[more]