Whole genome sequencing reveals high-resolution epidemiological links between clinical and environmental Klebsiella pneumoniae.

ABSTRACT:

Background

Klebsiella pneumoniae is a gram-negative bacterial species capable of occupying a broad range of environmental and clinical habitats. Known as an opportunistic pathogen, it has recently become a major causative agent of clinical infections worldwide. Despite growing knowledge about the highly diverse population of K. pneumoniae, the evolution and clinical significance of environmental K. pneumoniae, as well as the relationship between clinical and environmental K. pneumoniae, are poorly defined.

Methods

We isolated and sequenced K. pneumoniae from in-patients in a single hospital in Thailand, as well as hospital sewage, and surrounding canals and farms within a 20-km radius.

Results

Phylogenetic analysis of 77 K. pneumoniae (48 clinical and 29 non-clinical

SUBMITTER: Runcharoen C 

PROVIDER: S-EPMC5264300 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature