Breed and adaptive response modulate bovine peripheral blood cells' transcriptome.

ABSTRACT:

Background

Adaptive response includes a variety of physiological modifications to face changes in external or internal conditions and adapt to a new situation. The acute phase proteins (APPs) are reactants synthesized against environmental stimuli like stress, infection, inflammation.

Methods

To delineate the differences in molecular constituents of adaptive response to the environment we performed the whole-blood transcriptome analysis in Italian Holstein (IH) and Italian Simmental (IS) breeds. For this, 663 IH and IS cows from six commercial farms were clustered according to the blood level of APPs. Ten extreme individuals (five APP+ and APP- variants) from each farm were selected for the RNA-seq using the Illumina sequencing technology. Differentially expressed (DE) genes

SUBMITTER: Poscic N 

PROVIDER: S-EPMC5264304 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature