Infecting HIV-1 Subtype Predicts Disease Progression in Women of Sub-Saharan Africa.

ABSTRACT:

Introduction

Long-term natural history cohorts of HIV-1 in the absence of treatment provide the best measure of virulence by different viral subtypes.

Methods

Newly HIV infected Ugandan and Zimbabwean women (N=303) were recruited and monitored for clinical, social, behavioral, immunological and viral parameters for 3 to 9.5years.

Results

Ugandan and Zimbabwean women infected with HIV-1 subtype C had 2.5-fold slower rates of CD4 T-cell declines and higher frequencies of long-term non-progression than those infected with subtype A or D (GEE model, P<0.001), a difference not associated with any other clinical parameters. Relative replicative fitness and entry efficiency of HIV-1 variants directly correlated with virulence in the patients, subtype D>A>C (P<0.001, ANOVA).<

SUBMITTER: Venner CM 

PROVIDER: S-EPMC5264310 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature