Mitochondrial and Chromosomal Damage Induced by Oxidative Stress in Zn²⁺ Ions, ZnO-Bulk and ZnO-NPs treated Allium cepa roots.

ABSTRACT: Large-scale synthesis and release of nanomaterials in environment is a growing concern for human health and ecosystem. Therefore, we have investigated the cytotoxic and genotoxic potential of zinc oxide nanoparticles (ZnO-NPs), zinc oxide bulk (ZnO-Bulk), and zinc ions (Zn²⁺) in treated roots of Allium cepa, under hydroponic conditions. ZnO-NPs were characterized by UV-visible, XRD, FT-IR spectroscopy and TEM analyses. Bulbs of A. cepa exposed to ZnO-NPs (25.5 nm) for 12 h exhibited significant decrease (23 ± 8.7%) in % mitotic index and increase in chromosomal aberrations (18 ± 7.6%), in a dose-dependent manner. Transmission electron microcopy and FT-IR data suggested surface attachment, internalization and biomolecular intervention of ZnO-NPs in root cells, respectively. The l

SUBMITTER: Ahmed B 

PROVIDER: S-EPMC5264391 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature