Association between the -159C/T polymorphism in the promoter region of the CD14 gene and sepsis: a meta-analysis.

ABSTRACT:

Background

The association between CD14-159C/T polymorphism and sepsis has been assessed but results of current studies appeared conflicting and inconstant. This analysis was aimed to determine whether the CD14-159C/T polymorphism confers susceptibility to sepsis or is associated with increased risk of death from sepsis.

Method

The authors conducted a comprehensive search of PubMed, EMBASE, ISI Web of Science, Cochrane library, ScienceDirect, Wiley Online Library and CNKI databases according to a prespecified protocol. Language limits were restricted to English and Chinese. Two reviewers independently selected the articles and extracted relevant data onto standardized forms. Disagreements were settled by discussion and suggestions from senior consultants. The strength of ass

SUBMITTER: Wu Q 

PROVIDER: S-EPMC5264438 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature