D-Cycloserine enhances durability of social skills training in autism spectrum disorder.

ABSTRACT:

Background

d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conducted a placebo-controlled trial of DCS to potentiate social skills training in autism spectrum disorder (ASD) but found substantial improvement in both the DCS and placebo groups at the conclusion of active treatment. Here, we assess the impact of DCS 11 weeks following active treatment to evaluate the impact of DCS on treatment response durability.

Methods

Study participants included 60 outpatient youth with ASD, ages 5-11 years, all with IQ above 70, and significantly impaired social functioning who completed a 10-week active treatment phase during which they received weekly single d

SUBMITTER: Wink LK 

PROVIDER: S-EPMC5264460 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature