Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial.

ABSTRACT:

Background

The gut microbiota is interlinked with obesity, but direct evidence of effects of its modulation on body fat mass is still scarce. We investigated the possible effects of Bifidobacterium animalisssp. lactis 420 (B420) and the dietary fiber Litesse® Ultra polydextrose (LU) on body fat mass and other obesity-related parameters.

Methods

225 healthy volunteers (healthy, BMI 28-34.9) were randomized into four groups (1:1:1:1), using a computer-generated sequence, for 6months of double-blind, parallel treatment: 1) Placebo, microcrystalline cellulose, 12g/d; 2) LU, 12g/d; 3) B420, 10¹⁰CFU/d in microcrystalline cellulose, 12g/d; 4) LU+B420, 12g+10¹⁰CFU/d. Body composition was monitored with dual-energy X-ray absorptiometry, and the primary outcome w

SUBMITTER: Stenman LK 

PROVIDER: S-EPMC5264483 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature