Oral, ultra-long-lasting drug delivery: Application toward malaria elimination goals.

ABSTRACT: Efforts at elimination of scourges, such as malaria, are limited by the logistic challenges of reaching large rural populations and ensuring patient adherence to adequate pharmacologic treatment. We have developed an oral, ultra-long-acting capsule that dissolves in the stomach and deploys a star-shaped dosage form that releases drug while assuming a geometry that prevents passage through the pylorus yet allows passage of food, enabling prolonged gastric residence. This gastric-resident, drug delivery dosage form releases small-molecule drugs for days to weeks and potentially longer. Upon dissolution of the macrostructure, the components can safely pass through the gastrointestinal tract. Clinical, radiographic, and endoscopic evaluation of a swine large-animal model that received these do

SUBMITTER: Bellinger AM 

PROVIDER: S-EPMC5264553 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature