Mechanistic insights into the impact of Cold Atmospheric Pressure Plasma on human epithelial cell lines.

ABSTRACT: Compelling evidence suggests that Cold Atmospheric Pressure Plasma (CAPP) has potential as a new cancer therapy. However, knowledge about cellular signaling events and toxicity subsequent to plasma treatment is still poorly documented. The aim of this study was to focus on the interaction between 3 different types of plasma (He, He-O₂, He-N₂) and human epithelial cell lines to gain better insight into plasma-cell interaction. We provide evidence that reactive oxygen and nitrogen species (RONS) are inducing cell death by apoptosis and that the proteasome, a major intracellular proteolytic system which is important for tumor cell growth and survival, is a target of (He or He-N₂) CAPP. However, RONS are not the only actors involved in cell death; electric fiel

SUBMITTER: Dezest M 

PROVIDER: S-EPMC5264585 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature