Genome-wide association study identifies four SNPs associated with response to platinum-based neoadjuvant chemotherapy for cervical cancer.

ABSTRACT: To identify genomic markers associated with the response to neoadjuvant chemotherapy (NACT) in patients with cervical cancer, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. A total of 596 patients with stage IA2-IIIB cervical cancer were enrolled in this study. One single nucleotide polymorphism (SNP) (rs6812281, per allele OR = 2.37, P = 9.0 × 10^-9) located at 4q34.3 reached GWAS significance (P < 5.0 × 10^-8). Another three SNPs, rs4590782 (10q26.2, P = 1.59 × 10^-5, per allele OR = 0.48), rs1742101 (14q32.11, P = 7.11 × 10^-6, per allele OR = 0.52), and rs1364121 (16q23.3, P = 3.15 × 10^-6, per allele OR = 1.98), exhibited strong evidence of associations with response to neoadjuvant chemot

SUBMITTER: Li X 

PROVIDER: S-EPMC5264598 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature