Identification of cardiac progenitors that survive in the ischemic human heart after ventricular myocyte death.

ABSTRACT: Atypically-shaped cardiomyocytes (ACMs) are beating heart cells identified in the cultures of cardiomyocyte-removed fractions obtained from adult mouse hearts. Since ACMs spontaneously develop into beating cells in the absence of hormones or chemicals, these cells are likely to be a type of cardiac progenitors rather than stem cells. "Native ACMs" are found as small interstitial cells among ventricular myocytes that co-express cellular prion protein (PrP) and cardiac troponin T (cTnT) in mouse and human heart tissues. However, the endogenous behavior of human ACMs is unclear. In the present study, we demonstrate that PrP⁺ cTnT⁺ cells are present in the human heart tissue with myocardial infarction (MI). These cells were mainly found in the border of necrotic cardiomyo

SUBMITTER: Omatsu-Kanbe M 

PROVIDER: S-EPMC5264617 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature