Analysis of alternative splicing events for cancer diagnosis using a multiplexing nanophotonic biosensor.

ABSTRACT: Personalized medicine is a promising tool not only for prevention, screening and development of more efficient treatment strategies, but also for diminishing the side effects caused by current therapies. Deciphering gene regulation pathways provides a reliable prognostic analysis to elucidate the origin of grave diseases and facilitate the selection of the most adequate treatment for each individual. Alternative splicing of mRNA precursors is one of these gene regulation pathways and enables cells to generate different protein outputs from the same gene depending on their developmental or homeostatic status. Its deregulation is strongly linked to disease onset and progression constituting a relevant and innovative class of biomarker. Herein we report a highly selective and sensitive nanoph

SUBMITTER: Huertas CS 

PROVIDER: S-EPMC5264646 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature