Determining the Optimal Vaccination Schedule for Herpes Zoster: a Cost-Effectiveness Analysis.

ABSTRACT:

Background

The Advisory Committee on Immunization Practices recommends a single dose of herpes zoster (HZ) vaccine in persons aged 60 years or older, but the efficacy decreases to zero after approximately 10 years. A booster dose administered after 10 years might extend protection, but the cost-effectiveness of a booster strategy has not been examined.

Objective

We aimed to determine the optimal schedule for HZ vaccine DESIGN: We built a Markov model to follow patients over their lifetime. From the societal perspective, we compared costs and quality-adjusted life years (QALYs) saved of 11 strategies to start and repeat HZ vaccine at different ages.

Subjects

Adults aged 60 years.

Intervention

HZ vaccine.

Main measures

Costs, quality-adjusted life years (Q

SUBMITTER: Le P 

PROVIDER: S-EPMC5264671 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature