Renal denervation, adjusted drugs, or combined therapy for resistant hypertension: A meta-regression.

ABSTRACT: The objective of this study is to systematically evaluate the efficacy of renal denervation (RD), adjusted drugs, or combined therapy for resistant hypertension (RH) through a systematic review and meta-analysis of controlled studies.Publications were comprehensively searched. Studies that investigated the effects of RD and/or adjusted drugs in lowering blood pressure (BP) were included. After quality assessment and data extraction, subgroup analyzes were first performed according to blinding method. Meta-regression and inverted funnel plots were also conducted.A total of 13 studies containing 1604 RH patients were included. Compared with control, the meta-analysis showed that RD significantly reduced office-based BP and ambulatory BP in 6 months in the unblinded studies, while no signific

SUBMITTER: Qi XY 

PROVIDER: S-EPMC5265808 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature