Treatment efficacy of anti-hypertensive drugs in monotherapy or combination: ATOM systematic review and meta-analysis of randomized clinical trials according to PRISMA statement.

ABSTRACT:

Background

The relative efficacy of antihypertensive drugs/combinations is not well known. Identifying the most effective ones and the patients' characteristics associated with best performance of the drugs will improve management of hypertensive patients.

Objective

To assess the blood pressure (BP) reduction attributed to antihypertensive drugs and identify characteristics associated with BP decrease.

Data sources

MEDLINE, Cochrane Central Register of Controlled Trials from inception through July 2012 and selected papers.

Study eligibility criteria

Double-blind, randomized clinical trials whose main result was the reduction in BP by antihypertensive treatment, with study population ≥50 or ≥25 if the study was a crossover, follow-up of at least 8 weeks, and ava

SUBMITTER: Paz MA 

PROVIDER: S-EPMC5265817 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature