Association of genetic variants in the receptor for advanced glycation end products gene with diabetic retinopathy: A meta-analysis.

ABSTRACT:

Background

Diabetic retinopathy (DR) is a major sight-threatening diabetic complication. Previous studies have examined the association of DR with multiple genetic variants in the receptor for advanced glycation end products (RAGE) gene, with inconsistent results.

Objective

To perform a systematic literature search and conduct meta-analyses to examine the association of genetic variants in RAGE with DR.

Data sources

PubMed, Cochrane Library, Embase, Google Scholar, and HuGE.

Study eligibility criteria and participants

Studies were on human subjects; the studies were case-control ones and included subjects who had DR and those who did not have DR; and the studies provided genotype data for genetic variants in RAGE, separately for subjects who had and did not hav

SUBMITTER: Yu W 

PROVIDER: S-EPMC5265886 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature