Association of CD14 -159 (-260C/T) polymorphism and asthma risk: an updated genetic meta-analysis study.

ABSTRACT:

Background

It has been reported that the cluster of differentiation 14 (CD14) gene -159C/T variant may be associated with asthma risk. However, some studies yielded conflicting results. Therefore, a comprehensive meta-analysis was designed to assess the precise association.

Methods

A systematic search in PubMed, Embase (Ovid), China National Knowledge Internet (CNKI), and Wan fang databases was conducted up to August 15, 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to pool the effect size. We used I to assess heterogeneity, and a funnel plot and Egger test to assess publication bias.

Results

In total, 34 studies involving 15,641 subjects were included in this meta-analysis. There was a statistically significant association between CD14 -159C/T poly

SUBMITTER: Wang D 

PROVIDER: S-EPMC5265933 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature