Prognostic value of the lymphocyte monocyte ratio in patients with colorectal cancer: A meta-analysis.

ABSTRACT:

Background

Inflammation plays a critical role in the pathogenesis and progression of cancer. A low lymphocyte-to-monocyte ratio (LMR) is reported be a poor prognostic factor in multiple malignancies. We performed a meta-analysis to evaluate the prognostic role of preoperative LMR in colorectal cancer (CRC).

Methods

Studies investigating the prognostic role of preoperative LMR on survival in patients with CRC were systematically searched for in MEDLINE, EMBASE, Cochrane databases from inception up to August 2016. Pooled hazard ratios (HRs) for overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) were calculated using fixed-effects/random-effects models.

Results

A total of nine studies comprising 8626 patients with CRC were included in

SUBMITTER: Song W 

PROVIDER: S-EPMC5266021 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature