Role of immune cells in pancreatic cancer from bench to clinical application: An updated review.

ABSTRACT:

Background

Pancreatic cancer (PC) remains difficult to treat, despite the recent advances in various anticancer therapies. Immuno-inflammatory response is considered to be a major risk factor for the development of PC in addition to a combination of genetic background and environmental factors. Although patients with PC exhibit evidence of systemic immune dysfunction, the PC microenvironment is replete with immune cells.

Methods

We searched PubMed for all relevant English language articles published up to March 2016. They included clinical trials, experimental studies, observational studies, and reviews. Trials enrolled at Clinical trial.gov were also searched.

Results

PC induces an immunosuppressive microenvironment, and intratumoral activation of immunity in PC is a

SUBMITTER: Chang JH 

PROVIDER: S-EPMC5266022 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature