Importance of Altered Levels of SERCA, IP₃R, and RyR in Vascular Smooth Muscle Cell.

ABSTRACT: Calcium cycling between the sarcoplasmic reticulum (SR) and the cytosol via the sarco-/endoplasmic reticulum Ca-ATPase (SERCA) pump, inositol-1,4,5-triphosphate receptor (IP₃R), and Ryanodine receptor (RyR), plays a major role in agonist-induced intracellular calcium ([Ca²⁺]_cyt) dynamics in vascular smooth muscle cells (VSMC). Levels of these calcium handling proteins in SR get altered under disease conditions. We have developed a mathematical model to understand the significance of altered levels of SERCA, IP₃R, and RyR on the intracellular calcium dynamics of VSMC and to understand how variation in protein levels that arise due to diabetes contribute to different VSMC behavior and thus vascular disease. SR is modeled as a single continuous enti

SUBMITTER: Johny JP 

PROVIDER: S-EPMC5266201 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature