Incidence of Severe Neutropenia in HIV-Infected People Starting Antiretroviral Therapy in West Africa.

ABSTRACT:

Background

In sub-Saharan Africa, antiretroviral therapy (ART) including drugs with potential toxicity such as Zidovudine (ZDV) are routinely prescribed. This study aimed at estimating the incidence of severe neutropenia and associated factors after ART initiation in five West African countries.

Methods

A retrospective cohort analysis was conducted within the international epidemiologic database to evaluate AIDS (IeDEA) collaboration in West Africa. All HIV-infected adults, initiating ART between 2002 and 2014, with a baseline and at least one follow-up absolute neutrophil count (ANC) measurement were eligible. Incidence of severe neutropenia (ANC <750 cells/mm3) was estimated with 95% confidence interval (CI) according to age, gender, HIV clinic, hemoglobin, CD4 count, clin

SUBMITTER: Leroi C 

PROVIDER: S-EPMC5266303 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature