Concurrence of extracellular vesicle enrichment and metabolic switch visualized label-free in the tumor microenvironment.

ABSTRACT: Understanding the role of the tumor microenvironment in carcinogenesis has reshaped cancer research. Events at both microscopic (molecular) and macroscopic (tissue) scales have been identified in engineered tumor microenvironments involving in vitro cultures, live tissue xenografts, and transgenic animals. However, these events have not been comprehensively observed under unperturbed (authentic) conditions free of exogenous labeling or genetic modification. The lack of a suitable imaging methodology has largely limited our understanding of the complex interrelations and possible causal links involved in carcinogenesis and metastasis within the tumor microenvironment. Using multicontrast nonlinear imaging, we visualize endogenous substances in rat and human mammary tumors through their intr

SUBMITTER: Tu H 

PROVIDER: S-EPMC5266479 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature