Thyroid hormone treatment among pregnant women with subclinical hypothyroidism: US national assessment.

ABSTRACT:

Objective

 To estimate the effectiveness and safety of thyroid hormone treatment among pregnant women with subclinical hypothyroidism.

Design

 Retrospective cohort study.

Setting

 Large US administrative database between 1 January 2010 and 31 December 2014.

Participants

 5405 pregnant women with subclinical hypothyroidism, defined as untreated thyroid stimulating hormone (TSH) concentration 2.5-10 mIU/L.

Exposure

 Thyroid hormone therapy.

Main outcome measure

 Pregnancy loss and other pre-specified maternal and fetal pregnancy related adverse outcomes.

Results

 Among 5405 pregnant women with subclinical hypothyroidism, 843 with a mean pre-treatment TSH concentration of 4.8 (SD 1.7) mIU/L were treated with thyroid hormone and 4562 with a mea

SUBMITTER: Maraka S 

PROVIDER: S-EPMC5266622 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature