Staphylococcus aureus Protein A Disrupts Immunity Mediated by Long-Lived Plasma Cells.

ABSTRACT: Infection with Staphylococcus aureus does not induce long-lived protective immunity for reasons that are not completely understood. Human and murine vaccine studies support a role for Abs in protecting against recurring infections, but S. aureus modulates the B cell response through expression of staphylococcus protein A (SpA), a surface protein that drives polyclonal B cell expansion and induces cell death in the absence of costimulation. In this murine study, we show that SpA altered the fate of plasmablasts and plasma cells (PCs) by enhancing the short-lived extrafollicular response and reducing the pool of bone marrow (BM)-resident long-lived PCs. The absence of long-lived PCs was associated with a rapid decline in Ag-specific class-switched Ab. In contrast, when previously inoculated

SUBMITTER: Keener AB 

PROVIDER: S-EPMC5266639 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature