Shape Memory Silk Protein Sponges for Minimally Invasive Tissue Regeneration.

ABSTRACT: Porous silk protein scaffolds are designed to display shape memory characteristics and volumetric recovery following compression. Two strategies are utilized to realize shape recovery: addition of hygroscopic plasticizers like glycerol, and tyrosine modifications with hydrophilic sulfonic acid chemistries. Silk sponges are evaluated for recovery following 80% compressive strain, total porosity, pore size distribution, secondary structure development, in vivo volume retention, cell infiltration, and inflammatory responses. Glycerol-modified sponges recover up to 98.3% of their original dimensions following compression, while sulfonic acid/glycerol modified sponges swell in water up to 71 times their compressed volume, well in excess of their original size. Longer silk extraction times (lowe

SUBMITTER: Brown JE 

PROVIDER: S-EPMC5266640 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature