Lesions causing freezing of gait localize to a cerebellar functional network.

ABSTRACT:

Objective

Freezing of gait is a disabling symptom in Parkinson disease and related disorders, but the brain regions involved in symptom generation remain unclear. Here we analyze brain lesions causing acute onset freezing of gait to identify regions causally involved in symptom generation.

Methods

Fourteen cases of lesion-induced freezing of gait were identified from the literature, and lesions were mapped to a common brain atlas. Because lesion-induced symptoms can come from sites connected to the lesion location, not just the lesion location itself, we also identified brain regions functionally connected to each lesion location. This technique, termed lesion network mapping, has been recently shown to identify regions involved in symptom generation across a variety of lesi

SUBMITTER: Fasano A 

PROVIDER: S-EPMC5266642 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature