Systematic synthetic and biophysical development of mixed sequence DNA binding agents.

ABSTRACT: It is now well established that, although only about 5% of the human genome codes for protein, most of the DNA has some function, such as synthesis of specific, functional RNAs and/or control of gene expression. These functional sequences open immense possibilities in both biotechnology and therapeutics for the use of cell-permeable, small molecules that can bind mixed-base pair sequences of DNA for regulation of genomic functions. Unfortunately very few types of modules have been designed to recognize mixed DNA sequences and for progress in targeting specific genes, it is essential to have additional classes of compounds. Compounds that can be rationally designed from established modules and which can bind strongly to mixed base pair DNA sequences are especially attractive. Based on exten

SUBMITTER: Paul A 

PROVIDER: S-EPMC5266669 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature